Angiotensin-Converting Enzyme and Dipeptidyl Peptidase IV Inhibitors
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چکیده
منابع مشابه
Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema.
Angioedema is a potentially life-threatening adverse effect of angiotensin-converting enzyme inhibitors. Bradykinin and substance P, substrates of angiotensin-converting enzyme, increase vascular permeability and cause tissue edema in animals. Studies indicate that amino-terminal degradation of these peptides, by aminopeptidase P and dipeptidyl peptidase IV, may be impaired in individuals with ...
متن کاملAngiotensin-converting enzyme and dipeptidyl peptidase IV inhibitors: an increased risk of angioedema.
The incidence of diabetes is increasing and affects 180 million adults worldwide, including 24 million in the United States, or 7.8% of the population. In 2007, 1.6 million new cases were diagnosed in U.S. residents aged 20 years or more.1 Despite the large number of antidiabetic agents on the market, the condition is still inadequately controlled in 30% of affected patients.2 Among available t...
متن کاملInteractive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans.
Dipeptidyl peptidase-IV inhibitors improve glucose homeostasis in type 2 diabetics by inhibiting degradation of the incretin hormones. Dipeptidyl peptidase-IV inhibition also prevents the breakdown of the vasoconstrictor neuropeptide Y and, when angiotensin-converting enzyme (ACE) is inhibited, substance P. This study tested the hypothesis that dipeptidyl peptidase-IV inhibition would enhance t...
متن کاملDipeptidyl peptidase IV inhibitors and diabetes therapy.
Current type 2 diabetes therapies are mainly targeted at stimulating pancreatic beta-cell secretion and reducing insulin resistance. A number of alternative therapies are currently being developed to take advantage of the actions of the incretin hormones Glucagon-Like Peptide-1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP). These hormones are released from the small intestine i...
متن کاملAngiotensin converting enzyme inhibitors.
The purpose of this brief review is to separate the characteristic properties and side effects attributable to the pharmacology of the whole class of angiotensin converting enzyme (ACE) inhibitors from those attributable to the chemical structure and kinetics of each particular ACE inhibitor. The former would be predictable and probably similar for all agents and, therefore, would be expected t...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2009
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.109.135244